Biodegradable and Biobased Polymers for Environmental and Biomedical Applications by Susheel Kalia

Author:Susheel Kalia
Format: epub
ISBN: 9781119117353
Publisher: John Wiley & Sons, Inc.
Published: 2016-01-27T16:00:00+00:00

7.6.1.5 Other Inorganic-based Fillers

In addition to the above-mentioned categories, other interesting types of inorganic fillers (such as hydroxyapatite (HA) or fluorapatite (FA)) are also mentioned in the literature, mostly for biomedical devices.

HA is acknowledged as the main component of bones and teeth, it features excellent bone bonding capability and osteoconductivity, and is used mainly as bone fillers or as a coating in reconstructive surgery. PBS/HA composites prepared by solution casting or melt blending have been reported [172,191]. Grigoriadou et al. [192], prepared PBS nanocomposites containing strontium HA [Sr5(PO4)3OH] nanorod: strontium seems to promote bone formation in tissue scaffolds. It was found that nanoparticles accelerate the hydrolysis degradation process thanks to the hydrophilicity of nanofillers; in fact, the presence of hydroxyl groups and the effect of a “gap” at the interface favours the release of filler during hydrolysis.

A new bone repair biomaterials is FA, which is structurally and chemically similar to HA, and is known to be more chemically stable and easier to synthesize. Additionally, FA can provide fluoride release at a controlled rate and several studies demonstrated the stimulating effect of fluoride on bone formation, therefore these composites have been successfully prepared by co-solution method [193].

Other PBS composites with wollastonite [194,195], β-Ca3(PO4)2 [196] and CaCO3 [197] are reported in literature.

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